KMID : 1143220200630020126
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Obstetrics & Gynecology Science 2020 Volume.63 No. 2 p.126 ~ p.132
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Subsequent pregnancy outcomes according to the presence of acute histologic chorioamnionitis in women with spontaneous preterm delivery
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Kim Nam-Kyeong
Choi Yae-Ji Hong Su-Been Park Jee-Yoon Oh Kyung-Joon Hong Joon-Seok
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Abstract
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Objective: To compare subsequent pregnancy outcomes according to the presence of acute histologic chorioamnionitis (HCA) in women with spontaneous preterm delivery (SPTD).
Methods: Among 1,706 women who gave birth twice or more at our institution, 138 women delivered spontaneously at preterm (<37.0 weeks). Subsequent deliveries occurred at our institution and placental biopsy results were available. The study population was categorized into 2 groups based on the presence of acute HCA at the time of SPTD: HCA group (n=52) and non-HCA group (n=86). The primary outcome measures were gestational age at delivery, birthweight, and frequency of preterm delivery in subsequent pregnancies.
Results: The median gestational age at the time of SPTD was 34.0 weeks (interquartile range [IQR], 28.9?35.3 weeks), and the frequency of acute HCA was 52/138 (38%). There were no differences in gestational age at delivery, birthweight, and frequency of preterm delivery between the HCA group and non-HCA group (median gestational age at delivery, 38.0 weeks (IQR, 36.7?38.8 weeks) in the HCA group vs. 37.9 weeks (IQR, 35.7?39.0 weeks) in the non-HCA group; frequency of preterm delivery, 14/52 (27%) in the HCA group vs. 33/86 (38%) in the non-HCA group; and median birthweight, 3.14 kg (IQR, 2.64?3.45 kg) in the HCA group vs. 2.95 kg (IQR, 2.44?3.36 kg) in the non-HCA group; P>0.1 for all.
Conclusion: The presence of acute HCA in women at prior SPTD did not significantly affect their subsequent pregnancy outcomes.
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KEYWORD
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Acute histologic chorioamnionitis, Preterm delivery, Recurrent preterm delivery, Placenta, Funisitis
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